北京大学药学院副教授
联系方式
fanaili@bmju.edu.cn
教育经历
2011.9-2015.8 德国马尔堡大学药学系，博士（药学与生物技术专业）
2005.9-2011.7 北京大学药学院,学士硕士（药学专业）
科研与学术工作经历：
2017.9-至今 北京化工大学生命科学与技术学院，副教授，硕士生导师
2015.10-2017.8 中国科学院微生物研究所，助理研究员
主要研究领域
1. 真菌次级代谢产物的生物合成及调控
2. 真菌次级代谢产物合成途径中关键酶的鉴定及催化机制研究
3. 利用合成生物学技术进行低劣生物质的无害化与资源化
主持或参加科研项目
国家自然科学基金青年基金，2019-2020，21万，项目负责人
科技部重点研发计划，2019-2024，93万/2450万，子课题负责人
国家自然科学基金重点基金，2019-2023，主要参与人
国家自然科学基金国际合作与交流项目，2020-2023，主要参与人
期刊论文及专利
1) Wei, H., Wu, M., Fan, A.(Fan, Aili)* and Su, H.* (2020). Recombinant protein production in the filamentou fungus Trichoderma. Chinese J. Chem. Eng., online.
2) Yu, X., Wei, H., Liu, X., Liu, D., Fan, A.* and Su, H. (2020). Enhanced resistance of Trichoderma harzianum LZDX-32-08 to hygromycin B induced by sea salt. Biotechnol Lett., online.
3) Wang, L., Yu, X., Xiong, W., Li, P., Wang, S., Fan, A.(Fan, Aili)* and Su, H.* (2020). Enhancing robustness of aerobic granule sludge under low C/N ratios with addition of kitchen wastewater. J. Environ. Manage. 265: 110503.
4) Yang, K., Li, S.-M., Liu, X.* and Fan, A.* (2020). Reinvestigation of the substrate specificity of a reverse prenyltransferase NotF from Aspergillus sp. MF297-2. Arch Microbiol. 202，1419-1424.
5) Li, W. #, Fan, A.#, Wang, L., Zhang, P., Liu, Z., An, Z., Yin, W.-B. (2018) Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi. Chem. Sci. 9, 2589-2594. (# contribute equally)
6) Fan, A.#, Mi, W. #, Liu, Z., Zeng, G., Zhang, P., Hu, Y., Fang, W., Yin, W.-B. (2017) Deletion of a histone acetyltransferase leads to the pleiotropic activation of natural products in Metarhizium robertsii. Org. Lett. 19,1686-1689. (# contribute equally)
7) Fan, A. and Li, S.-M. (2016) Saturation mutagenesis on Arg244 of the tryptophan C4-prenyltransferase FgaPT2 leads to enhanced catalytic ability and different preferences for tryptophan-containing cyclic dipeptides. Appl. Microbiol. Biotechnol. 100, 5389-5399.
8) Fan, A., Xie, X. and Li, S.-M. (2015). Tryptophan prenyltransferases showing higher catalytic activities for Friedel-Crafts alkylation of o- and m-tyrosine than tyrosine prenyltransferases. Org. & Biomol. Chem. 13, 7551-7557.
9) Fan, A., Winkelblech, J. and Li, S.-M. (2015). Impacts and perspectives of prenyltransferases of the DMATS superfamily for use in biotechnology. Appl. Microbiol. Biotechnol. 99, 7399-7415. (review).
10) Fan, A., Zocher, G., Stec, E., Stehle, T., and Li, S.-M. (2015). Site-directed mutagenesis switching a dimethylallyl tryptophan synthase to a specific tyrosine C3-prenylating enzyme. J. Biol. Chem. 290, 1364-1373.
11) Fan, A. and Li, S.-M. (2014). Prenylation of tyrosine and derivatives by a tryptophan C7-prenyltransferase. Tetrahedron Lett. 55, 5199-5202.
12) Fan, A., Chen, H., Wu, R., Xu, H., and Li, S.-M. (2014). A new member of the DMATS superfamily from Aspergillus niger catalyzes prenylations of both tyrosine and tryptophan derivatives. Appl. Microbiol. Biotechnol. 98, 10119-10129.
13) Fan, A. and Li, S.-M. (2013). One substrate - seven products with different prenylation positions in one-step reactions: prenyltransferases make it possible. Adv. Synth. Catal. 355, 2659-2666.
14) Fan, A., Lin, W., and Jia, Y. (2011) Recent research progress in the research on lamellarins and related pyrrole-derived alkaloids from marine organisms. J. Chin. Pharm. Sci. 20, 425–441. (Invited review)
15) Zheng, L., Yang, Y., Wang, H., Fan, A., Zhang, L. and Li, S. M. (2020). Ustethylin Biosynthesis Implies Phenethyl Derivative Formation in Aspergillus ustus. Org Lett. online.
16) Zheng, L., Wang, H., Fan, A. and Li, S. M. (2020). Oxepinamide F biosynthesis involves enzymatic D-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration. Nat Commun 11(1): 4914.
17) He, Y., Fan, A., Han, M., Zhang, Y., Tong, Y., Zheng, G. and Zhu, S. (2020) New perspectives on the treatment of mycobacterial infections using antibiotics. Appl. Microbiol. Biotechnol. 104, 4197-4209.
18) Xiong, W., Wang, L., Zhou, N., Fan, A., Wang, S. and Su, H. (2020). High-strength anaerobic digestion wastewater treatment by aerobic granular sludge in a step-by-step strategy. J. Environ. Manage. 262: 110245.
19) Zheng, L.‡, Mai, P.‡, Fan, A. and Li, S.-M. (2018). Switching a regular tryptophan C4-prenyltransferase to a reverse tryptophancontaining cyclic dipeptide C3-prenyltransferase by sequential site-directed mutagenesis. Org. & Biomol. Chem. 16, 6688-6694.
20) Zhang, P., Wang, X., Fan, A., Zheng, Y., Liu, X. Z., Wang, S., Zou, H., Oakley, B. R., Keller, N.P. and Yin, W.-B.* (2017). A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici. Mol. Microbiol. 105, 469–483.
21) Zhao, W., Fan, A., Tarcz, S., Zhou, K., Yin, W.-B., Liu, X.-Q., Li, S.-M.(2016). Mutation on Gly115 and Tyr205 of the cyclic dipeptide C2-prenyltransferase FtmPT1 increases its catalytic activity toward hydroxynaphthalenes. Appl. Microbiol. Biotechnol. 101, 1989-1998.
22) Winkelblech, J., Fan, A. and Li, S.-M. (2015). Prenyltransferases as key enzymes in the biosynthesis of prenylated natural products. Appl. Microbiol. Biotechnol. 99, 7379-7397. (review).
23) Pockrandt, D., Ludwig, L., Fan, A., Konig, G. M., and Li, S.-M. (2012). New insights into the biosynthesis of prenylated xanthones: XptB from Aspergillus nidulans catalyses an O-prenylation of xanthones. Chembiochem. 13, 2764-2771.
24) Li, Q., Fan, A., Lu, Z., Cui, Y., Lin, W., and Jia, Y. (2010) One-Pot AgOAc-Mediated Synthesis of Polysubstituted Pyrroles from Primary Amines and Aldehydes: Application to the Total Synthesis of Purpurone. Org. Lett. 12, 4066–4069.
25) Li, Q., Jiang, J., Fan, A., Cui, Y., and Jia, Y. (2011) Total Synthesis of Lamellarins D, H, and R and Ningalin B. Org. Lett. 13, 312–315.
26) Chinese patent application No. 202011082163.0 （哈茨木霉酸A化合物以及产该化合物的哈茨木霉突变株）
27) Chinese patent application No. 202010808145.X （一种虫草素基因工程菌及其应用）
28) Chinese patent application No. 201610312406.2 (授权，Asperphenamate合成相关蛋白及其编码基因与应用的制作方法)
29) Chinese patent application No. 201110077956.8
