PEOPLE
LIN Wenhan:
Professor
E-mail: whlin@bjmu.edu.cn
Research Areas
Marine Natural Product Chemistry
Education & Positions
University of Science and Technology of China (USTC), B.S., 1994
Massachusetts Institute of Technology, Ph.D., 2000
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, MS and Ph.D, 1985-1990
School of Pharmaceutical Sciences, Peking University, postdoctoral fellow, 1990-1992
School of Pharmaceutical Sciences, Peking University, associate professor, 1992-1996
School of Pharmaceutical Sciences, Peking University, professor, 1996-present
Federal University of Rio de Janeiro (Brazil), visiting researcher, 1993-1994
Faculty of Pharmaceutical Sciences, Toho University (Japan), visiting researcher, 1995-1996
Duesseldorf University (Germany), visiting professor, 1999-2000
Faculty Accolades
Director of marine drug division of CPA 2015-present
Mercator-Fellow (Germany) 2017
Natural Science and TechnologyAward of CPA 2008
Chinese Young ChemistAward 2004
Research Interests
Our research interesting mainly focus on the bioactive metabolites derived from marine organisms (sponges and corals), marine mangrove plants and their associated microorganisms. The research work included the isolation, structure elucidation of novel natural products, bioassay of the obtained compounds, and structural modification of bioactive products for further new drug development, and the interreaction of drugs and target proteins. So far, we examined more than 50 species of marine organisms inhabited in South China Sea chemically, and more than 3500 natural products to be isolated, of which more than 400 new compounds are characterized. Part of them showed potent bioactivities including and HIV-1, anti-cancers, and other activities. Up to date,we published more than 200 papers in scientific journals, involving Org. Lett., Tetrahedron, JNP, EJMC, BMC, and Phytochemistry, more than 10 patients related to bioactive natural products were awarded.
Grants and fundings
National Natural Science Foundation of China (81630089, U1406402-1, 41376127, 30930109)
MOST-Hightech 973 Program (2015CB755906)
National Deep Sea Plan (DY135-B-05)
NSFC-TAMU (41411120224)
NSFC-DFG (GZ816)
(RMB>1,000,000)
Principal Investigator
Publications
1. S. Niu, L. Si, D. Liu, A. Zhou, Z. Zhang, Z. Shao, S. Wang, L. Zhang, D. Zhou, W. Lin*. Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus. Euro. J. Med. Chem. 2016, 108, 229-244.
2. X. Chen, L. Si,D. Liu, P. Proksch, L. Zhang, D. Zhou,*W. Lin*. Neoechinulin B and its analoguesas potential entry inhibitors of influenza viruses, targeting viral hemagglutinin. Eur. J. Med. Chem. 2015, 93, 182-195.
3. H. Long,Z. Cheng,W. Huang,Q. Wu,X. Li,J. Cui,P. Proksch, W. Lin*. Diasteltoxins A？C, asteltoxin-based dimers from a mutant of the sponge-associated Emericella variecolor fungus. Org. Lett. 2016, 18, 4678？4681.
4. D. Liu, H. Lin, P. Proksch, X. Tang, Z. Shao,, W. Lin* Microbacterins A and B, unusual peptaibols from the deep-sea actinomyceteMicrobacterium sediminis sp. nov. YLB-01(T). Org. Lett. 2015, 17 (5), 1220-1223.
5. A. Yang, L. Si, Z. Shi, L. Tian,D. Liu, D. Zhou,P. Proksch, W. Lin* “Nitrosporeusines A and B, unprecedented thioester-bearing alkaloids from the ArcticStreptomyces nitrosporeus” Org. Lett. 2013, 15, 5366-5369.
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