Cheng Wei:

Research Associate Professor

E-mail: chengwei@bjmu.edu.cn

Research Areas

Natural Product Chemistry

Education & Positions

University of Science and Technology of China (USTC), B.S., 1994
Massachusetts Institute of Technology, Ph.D., 2000
Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS&PUMC), Ph.D., 2006-2009
Peking University Health Science Center, Lecturer 2009-

Research Interests

Our research is mainly focused on marine benthic organisms including corals and sponges of South China Sea. Base on in-depth biodiversity and chemical diversity investigation, we are engaging in the discovery of characteristic metabolites with novel structures and interesting activities. Our aim is to obtain lead compounds applied in medicinal research especially on aspects of anti-tumor, antibacteria and anti-virus.

Grants and fundings

National Natural Science Foundation of China (NSFC),“Discovery of anti-biofilm functional molecules base on the antifouling ecological features of marine natural products” (2017-2020, RMB 650,000) , Principal Investigator

Beijing Natural Science Foundation of China,“Studies on characteristic imidazole alkaloids derived from marine sponge Leucetta chagosensis and their anti-tumor activities” (2017-2019, RMB 200,000), Principal Investigator

Publications

1. Junjun Meng⁺, Wei Cheng⁺, Hajar Heydari⁺, Bin Wang, Kui Zhu, Belma Konuklugil, Wenhan Lin*. Sorbicillinoid-based Metabolites from a Sponge-derived Fungus Trichoderma saturnisporum. Marine Drugs, 2018, 16, doi:10.3390/md16070226.

2. Jingyuan Sun, JiruWu 1, Bang An, Nicole J. de Voogd, Wei Cheng*, Wenhan Lin*. Bromopyrrole Alkaloids with the Inhibitory Effects against the Biofilm Formation of Gram Negative Bacteria. Marine Drugs, 2018, 16: doi: 10.3390/md16010009.

3. Wei Cheng, Ming Ji, Xiaodan Li, Jinwei Ren, Fuling Yin, Leen van Ofwegen, Siwang Yu, Xiaoguang Chen, Wenhan Lin*. Fragilolides A-Q, norditerpenoid and briarane diterpenoids from thegorgonian coralJunceella fragilis. Tetrahedron, 2017, 73: 2518-2528.

4. Wei Cheng, Zhen Liu, Yang Yu, Leen van Ofwegen, Peter Proksch, Siwang Yu*, Wenhan Lin*. An unusual spinaceamine-bearing pregnane from a soft coral Scleronephthya sp. inhibits the migration of tumor cells. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 2736-2741.

5. Wei Cheng, Jinwei Ren, Qixi Huang, Hailin Long, Hongwei Jin, Liangren Zhang, Huagang Liu, Leen van Ofwegen, Wenhan Lin*. Pregnane steroids from a gorgonian coral Subergorgia suberosa with anti-flu virus effects. Steroids, 2016, 108: 99-104.